Macula densa-dependent and non-macula densa-dependent signaling in the juxtaglomerular apparatus
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................................................................................................................. 75 ABSTRACT IN HUNGARIAN (ÖSSZEFOGLALÁS) ............................................ 76IN HUNGARIAN (ÖSSZEFOGLALÁS) ............................................ 76
منابع مشابه
Oscillating cortical thick ascending limb cells at the juxtaglomerular apparatus.
While studying the intracellular calcium dynamics in cells of the macula densa, the observation was made that tubular epithelial cells located near the macula densa and associated with the renal arterioles exhibit spontaneous Ca2+ oscillations. In this study, the cortical thick ascending limb-distal tubule, with attached glomerulus, was isolated and perfused. At a low luminal sodium chloride co...
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Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis...
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It is well established that two microanatomical areas of the kidney (macula densa and juxtaglomerular cells) are in some way associated with the secretion of renin. However, their precise role in the regulation of this hormone remains unresolved. Controversy still exists as to whether the rate of renin secretion is controlled solely by a pressure and stretch sensitive receptor in the juxtaglome...
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Previous results from our laboratory have shown that in the isolated perfused juxtaglomerular apparatus, nonselective inhibitors of cyclooxygenase (COX) activity prevent the stimulation of renin secretion by a reduction in luminal NaCl concentration at the macula densa. The present studies were performed to examine which COX isoform is involved in NaCl-dependent renin secretion. In the absence ...
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Annexin A1 (ANXA1) exerts anti-inflammatory effects through multiple mechanisms including inhibition of prostaglandin synthesis. Once secreted, ANXA1 can bind to G protein-coupled formyl peptide receptors (Fpr) and activate diverse cellular signaling pathways. ANXA1 is known to be expressed in cells of the juxtaglomerular apparatus, but its relation to the expression of cyclooxygenase 2 (COX-2)...
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